← back

Live Openings

Staff / founding systems + data-engineering roles across the joined arms — HFT/trading, crypto-systems, fintech/quant, and biotech data-plane (same skillset: Rust/Go/Python, low-latency high-throughput data). Each links to the company's job board (deep job-IDs expire, so links point at the board; search the role there). Colours = reachability (EU-only, no US relocation): 🟢 EU-reachable · 🟡 EU-remote / situational · 🔴 US — reference only, not reachable.
updated 2026-08-17 · companies profiled in the Opportunity Catalogue · roles in the Positions Catalogue

🔴 EU-only. US roles below (on-site and US-remote, which need US work authorization) are red — reference only. Your reachable roles are all in 🟢 Apply now (22, EU-green + UK-visa-yellow, each flagged with comp or a comp: unknown tag).

🟢 Staff / Principal / CTO — remote, Rust / Go / Python

Refined lens (Kron 2026-08-13): staff / principal / CTO / founding only — not senior. Remote-first, Rust/Go/Python primary. Genuine remote-EU staff seats are thin; these are the real ones. Relay (cross-chain solver) stays the aspirational anchor but has no EU-remote seat now.

🟢 Douro Labs (Pyth Network) — Staff Engineer, Market Data · EU-remote
$87–150k · Rust; real-time market-data infra for DeFi. apply →
🟢 Grafana Labs — Staff Backend Engineer (Second Horizon / App Platform) · Remote EU (DE/ES/SE/UK/IE)
€109–131k / £103–124k · Go; observability DB internals (Loki/Mimir/Tempo). Two staff seats open. apply →
🟢 CoW DAO — Staff Backend Engineer, Rust · Remote EU-pref (±4h CEST)
comp: unknown (token plan) · Rust; DeFi DEX-aggregator ($200B+ lifetime volume). apply →
🟢 Stream — Staff Software Engineer (Go) · Remote EU (Amsterdam optional)
€110–160k + equity · Go + Rust; chat/video API infra at scale (CockroachDB/Postgres/Redis). apply →
🟢 Ethena Labs — Staff Trading Technology Engineer · Remote global
$150–230k · Python/TS (not Rust/Go) — feed handlers, algo/execution/backtesting. Pure trading-systems. apply →
🟡 Monzo — Staff / Senior Staff Backend Engineer · UK-remote (needs UK right-to-work) / Barcelona hybrid
£130–170k + equity · Go; bank-scale backend platform. apply →
🟡 Chainguard — Staff Software Engineer (Customer Platform) · Remote UK (+US/CA)
$205–231k · Go; supply-chain security platform. UK-flagged only. apply →
🟡 ClickHouse — Principal Software Engineer, Postgres · Netherlands (remote NL only)
comp: unknown · C++ / database internals. apply →
senior IC — below the staff bar (reference only)

Real Rust/Go seats but titled Senior, not Staff — apply only if they open a staff/principal seat: Keyrock (Rust HFT, EU-remote; its lead/staff seats are US-only), Offchain Labs (Rust), Alpaca (Go), Flashbots (Rust/Go MEV), Kraken (Rust), QuestDB (Rust/C++ DB), Nethermind (Rust/Go), Braiins (Rust, Prague), IOG (Rust), GoCardless (Go). Not reachable: P2P.org (UK-only contractor), Flow Traders (Amsterdam on-site, no live roles).

🟢 Apply now — EU-reachable roles

Every reachable role in one list, ranked, each with a reachability flag and pay. Comp is shown where the posting states it or a source (levels.fyi / Glassdoor) pins it; comp: unknown means it isn't published — usually an early / equity-heavy or unstated seat, so ask at first contact. Founding / early seats are folded in here now, not a separate list. Deadlines: Pfizer UK 7/28 · Genomics England Principal Data Eng Aug 2 · AstraZeneca Sr Director Aug 9.

🟡 Automata — Staff Platform Engineer · London hybrid (UK-visa) · EF-backed
£110–120k (Senior £70–80k) · Go + Rust + Temporal + K8s — the closest stack match in the set; lab-automation OS, multi-robot orchestration. apply →
🟢 RetinAI / Ikerian — Rust Engineer, Data Interoperability · Remote-EU
comp: unknown · Rust, medical-imaging data (DICOM/FHIR). Remote, no visa. apply →
🟢 Seqera — Staff Software Engineer (Unified Compute) · Spain-remote / Barcelona
comp: unknown · Nextflow/Fusion FUSE data plane + CRIU checkpoint, spot-instance resilience; Go+C core, Rust secondary. Best bio fit. apply →
🟢 Genestack — Staff Backend Engineer · Spain-remote / Belgrade
comp: unknown · Petabyte bio-data plane, ClickHouse/K8s. Remote confirmed. apply →
🟢 MiLaboratories — Senior Go Engineer · Bilbao, ES · on-site
comp: unknown · Go + distributed genomic data (MiXCR / Platforma.bio). On-site only. email stanp@milaboratories.com (subj "HN" + GitHub) →
🟢 Owkin — Sr Data Backend Engineer · Paris / remote
comp: unknown · Federated multimodal patient data, Python/Go/K8s. apply →
🟢 Cradle — Backend SWE (Python) · Zürich / Amsterdam
comp: unknown · Protein-design data, streaming/indexing. Documented EU-visa track record, low friction from Prague. apply →
🟢 Bioptimus — Technical Lead, Product / Data Operations · Paris / EU-remote · Sofinnova
comp: unknown · Foundation-model training infra for pathology + spatial transcriptomics + genomics. Re-verify currency. apply →
🟡 Ground Truth Labs — Software Engineer, Platform · Remote-UK · OSE
comp: unknown · Realtime AI-biomarker pipeline, bone-marrow imaging + spatial. Remote-first, UK right-to-work. Re-verify link is live. apply →
🟡 Isomorphic Labs — SWE, Compute Platform · London hybrid (UK-visa) · GV/Alphabet
£110–150k base (~$180–230k total), levels.fyi · AlphaFold-scale molecular data platform, GCP/GKE/GPU. Compute-Platform variant = lowest-level systems fit. apply →
🟡 Mytos — Senior SWE (Platform & Security) · London hybrid (UK-visa) · DSV/YC
comp: unknown · Go / Python / IoT — real-time hardware-data platform for automated cell manufacturing. Genuine Go role. apply →
🟡 Altos Labs — Staff AI Platform Engineer · Cambridge UK hybrid (UK-visa) · ARCH/Foresite/8VC
£97.3–128k · Multi-omics + microscopy at massive scale, FAIR data platform. Sponsorship possible. apply →
🟡 Healx — Platform Engineer (AWS/Terraform) · Cambridge hybrid (UK-visa) · CIC
comp: unknown · Infra + CI/CD + bioinformatics-pipeline productionisation for AI rare-disease discovery. apply →
🟡 Relation Therapeutics — Research Data / Platform Engineer · London hybrid (UK-visa)
comp: unknown · Lab-in-the-loop AI, genomics data lakehouse. Posted recently, high confidence. apply →
🟡 DNAnexus — SWE / Sr SWE · Prague · eng reqs expired — watch
comp: unknown · 125PB genomic data, 50B records/day — direct Prague/EU seat, but eng reqs currently expired (only PM live). Cold-outreach the eng leads + monitor weekly. careers →
🟢 Saphetor (VarSome) — C++ / Python Engineer, variant pipeline · Remote-EU · new 2026-07-27
comp: unknown · VarSome — genome-scale variant annotation; C++ high-throughput calling pipeline + Django/DRF over 150+ data sources. Fully remote EU. apply →
🟢 Parse Biosciences — (Senior) Bioinformatics Engineer · Remote EU/UK · new 2026-07-27
€50–85k / ~€65–120k Sr · Trailmaker single-cell analysis pipelines, Python/R/Nextflow/AWS. Remote EU confirmed. apply →
🟢 SOPHiA Genetics — Senior AI Software Engineer · Bidart, FR (hybrid) · also Rolle CH · new 2026-07-27
comp: unknown · Cloud genomics platform (SOPHiA DDM), Java microservices + K8s, staff-scope. Bidart = EU no-visa. apply →
🟡 Substrate Bio — Founding Software Engineer · London (onsite, UK-visa) · new 2026-07-27
comp: unknown · Lab orchestrator + data-capture layer routing every run into structured datasets. Pure data-plane, Python-first, founding seat — watch: no staff-engineer role, founding-SWE only. apply →
🟡 GenBio AI — Bioinformatics Data Engineer · Paris (hybrid, UK/EU-visa) · new 2026-07-27
comp: unknown · Foundation-model data pipelines (RNA-seq / multi-omics), Python/Ray/Kubeflow. Paris EU office. apply →
🟡 Basecamp Research — Senior Platform Engineer · London (UK-visa) · watch · new 2026-07-27
comp: unknown · Petascale metagenomics KB, Python/Go, K8s, ClickHouse, Dagster, Temporal — exact data-plane stack. Req currently filled/404 — watch the board. careers →
🟡 GRAIL — Staff Software Engineer, Lab Technology · London hybrid (UK right-to-work) · new 2026-08-10
comp: unknown (staff, London — credibly clears) · Go/Python, production data-intensive systems over the clinical-sequencing data lifecycle (raw lab → analysis-ready, schema evolution, consent/privacy at scale). Regulated-env background wanted; 7+ yrs. US parent, this seat is London. apply →
how this list was built

Fanned across YC/startup boards, frontier-lab careers pages, platform employers, and biotech job aggregators (BioSpace, Built In, Wellfound), then fetched every apply URL to confirm it's a real, currently-open posting and cross-checked comp against the posting, levels.fyi, or Glassdoor. Entries where the posting itself states a salary that reaches $160k are 🟢; frontier labs that hide pay but credibly clear $160k (SF/Boston/London senior AI-bio seats) are 🟡 with the comp source named per row. Closed or sub-threshold roles are listed under honest gaps, not padded into the count.

🔴 US — salary stated (reference only, 9)

All US / Canada — not reachable without US relocation (you're EU-only). Kept only for the salary reference (these are real posted $160k+ bands). Your actual targets are the EU roles up top →

Pfizer — Sr. Director, Engineering Lead · 29 US locations · in-office or remote
$215k–$358k. AI-first platforms, architecture, DevOps, Python. Senior-management track — top-of-band pharma seat. apply →
Profluent — Machine Learning Research Engineer · Emeryville, CA · hybrid (2-3d SF Bay)
$200k–$330k base + equity + 401(k). Protein language models; PyTorch, transformers, CUDA/Triton, FSDP, K8s. apply →
Xaira Therapeutics — BioMedical AI Research Engineer · South San Francisco, CA · onsite
$190k–$280k base + bonus + equity. PyTorch/JAX/TF, LLMs, agent orchestration, knowledge graphs, multimodal foundation models. apply →
Xaira Therapeutics — AI Research Engineer · South SF / Seattle · onsite
$190k–$280k base + bonus + equity. Python, PyTorch, deep learning for therapeutic discovery; 5+ yrs industry AI/ML. apply →
OneStudyTeam (clinical-trial SaaS) — Director, Engineering · Remote, USA
$180k–$230k. Full-stack + cloud, clinical-trial platform. Fully remote US, director level. apply →
Profluent — Senior Software Engineer, Data Platform · Emeryville, CA · hybrid
$170k–$220k base + equity + 401(k). Python, GCP, PostgreSQL, BigQuery, workflow orchestration. apply →
Freenome — Senior Software Engineer II · Remote, USA
$162k–$227k. Python, cloud data pipelines, ML for cancer early-detection. Fully remote US — rare at this band. apply →
Recursion Pharmaceuticals — Engineering Manager, Machine Learning · Toronto, Canada · fully remote (CA)
CAD 210k–283k (≈ $155k–$208k USD base) + bonus + equity. Python, PyTorch, Ray, Prefect, GCP, CUDA. Base floor sits just under $160k USD; total comp clears it. apply →
Ginkgo Bioworks — Senior Software Engineer, Autonomous Lab (Catalyst) · Boston, MA · onsite (reloc offered)
$134k–$190k base + stock; top of band clears $160k, total comp with equity >$180k. Python/TS/React, C#/.NET, K8s, Kafka, Temporal, GCP/AWS. apply →

Frontier labs — comp estimated (12)

Mixed reachability: 🟢 Isomorphic Labs (London ×3) is EU-reachable — the real targets here; 🟡 Iambic (Boston / Bristol-UK, remote) might take a UK-remote; 🔴 Chai (SF ×3), Insitro (SF ×2), Illumina (San Diego) are US — reference only.

Chai Discovery ($13B, OpenAI/Sequoia-backed) — Software Engineer, Platform & Inference · San Francisco · onsite
~$180k–$260k est. (posting says only "highly competitive"). GPU/CUDA kernels, inference infra, Slurm/K8s. apply →
Chai Discovery — Research Engineer · San Francisco · onsite
~$200k–$300k est. Model training/eval/optimization, core model infra, PyTorch. apply →
Chai Discovery — Software Engineer, Products · San Francisco · onsite
~$170k–$240k est. Web apps, React/Vue, product engineering, Python. apply →
Isomorphic Labs ($2.1B Series B) — Senior Software Engineer, Inference Platform · London, UK · hybrid 3d
£110k–£150k base (~$180k–$230k total w/ equity), levels.fyi. GCP, GKE, NVIDIA GPUs, TPU, large-scale ML inference. apply →
Isomorphic Labs — Software Engineer, Compute Platform · London, UK · hybrid
~$170k–$220k total est. GCP, Kubernetes, distributed compute, Python. apply →
Isomorphic Labs — ML Research Engineer · London, UK · hybrid
~$180k–$240k total est. PyTorch/JAX, ML research infra, drug-discovery models. apply →
Insitro — Senior Machine Learning Scientist, Imaging · South SF, CA · onsite/hybrid
~$210k–$300k total (levels.fyi median TC $270k). Python, computer vision, segmentation, microscopy ML. apply →
Insitro — (Senior) ML Scientist · South SF, CA · onsite/hybrid
~$200k–$290k total (levels.fyi median $270k). Python, graph-based modeling, systems biology, multimodal ML. apply →
Iambic Therapeutics — ML Scientist, Large Multimodal Models · Boston / Bristol UK · remote (US or UK)
~$160k–$215k (ML Scientist II/Sr band, Glassdoor). Python, large multimodal models, deep learning for drug discovery. apply →
Iambic Therapeutics — ML Scientist, Agentic Data Pipelines · Boston / Bristol UK · remote
~$160k–$215k (Glassdoor band). Python, agentic pipelines, ML data engineering. apply →
Iambic Therapeutics — Senior Software Engineer, Cloud Security · Boston, MA · hybrid / remote E-Coast
~$165k–$210k est. (senior SWE, San Diego/Boston). Python, cloud security, AWS/GCP. apply →
Illumina — Senior Software Engineer (platform/cloud) · San Diego / Foster City · hybrid
$162k median, up to ~$249k–$304k senior (levels.fyi). Cloud (AWS/Azure), backend services, bioinformatics pipelines. Link is the salary reference — search live reqs on the Illumina careers site. comp ref →

🚀 Founding / early-seat context & cold-outreach

The founding / early-SWE seats are now folded into Apply now above (flagged, with comp where known). They're the portfolio backdoor — equity-heavy early roles at VC-portfolio genomics/data companies, where funds drop engineers into their NewCos, sourced from a sweep across Flagship/Foresite/ARCH, a16z/Lux/8VC, EU funds, YC/Nucleate/EF. Stack reality: most are Python/Snowflake — the pitch is “trading-grade high-throughput systems → sequencing/imaging data plane,” not a keyword match. Companies to watch live on the Watchlist.

cold-outreach founding seats (no ad yet)

🟢 EU seats, no ad yet — cold-pitch the founders: OutSee (Ahren, Cambridge, seed), Enhanc3D Genomics (OSE/CIC, UK), WhiteLab Genomics (Paris).
🔴 US — reference only (no relocation): Strand AI & Origin Bio (YC W26, SF), Betteromics (ex-Google/GRAIL), Eikon (SF, PB/week imaging — the best domain match, but US), Novaflow (SF, Founding Backend Eng, Go/K8s).

Best 5 this week (all EU-reachable): Automata London (Go+Rust, apply) · Ground Truth Labs (remote-UK) · Cradle Zürich · Isomorphic Compute Platform, London · Mytos London (Go/IoT). Then cold-pitch the EU seats above (OutSee, Enhanc3D, WhiteLab).

Honest gaps — not counted above

Surfaced in the sweep but dropped, so the count above stays clean:

Fastest hard-confirmed shots: Profluent (both roles, salary on the posting, $170k floor), Xaira (both, $190k floor), Freenome (remote-US, $162k floor). Frontier upside without a stated number: Chai Discovery and Isomorphic. Companies profiled in the Opportunity Catalogue →; role archetypes & strategy in the Positions Catalogue →.